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KMID : 0043320090320050661
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Archives of Pharmacal Research
2009 Volume.32 No. 5 p.661 ~ p.666
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A New Triterpenoid from Brucea javanica
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Zhang Wei-Dong
Yan Shi Kai
Shen Yun-Heng
Chen Ming
Hu Xiao-Jia
Jin Hui Zi
Qin Jiang-Jiang
Liu Jian-Hua
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Abstract
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A new triterpenoid, bruceajavanin C (1), together with bruceosides A and B (2 and 3), bruceines D and E (4 and 5), yadanziosides A and G (6 and 7), (20R)-O-(3)-α-L-arabinopyranosylpregn- 5-ene-3β,20-diol (8), and α-D-glucopyranoside, (3β, 20R)-3-hydroxypregn-5-en-20-yl (9) were isolated from the aerial parts of Brucea javanica. The structure of 1 was elucidated on the basis of 2D-NMR spectroscopic analysis. In addition, compounds 1, 3, 4, 5, and 6 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.
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KEYWORD
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Brucea javanica, Triterpenoid, Bruceajavanin C, NO production
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